4th Annual Course of Academy of Immunohistochemistry
Diagnostic Immunohistochemistry and Molecular Pathology

Krakow, Poland, 18 – 20th October 2017


Joanna Applequist (Sweden)

is a European Patent Attorney and works at Groth & Co KB in Stockholm, a leading European Intellectual Property law firm. She works with drafting and prosecuting patent applications in Life Science worldwide, patentability assessments, prior-art searches and other intellectual property related issues. She is involved in freedom-to-operate analysis and validity investigations. Her competence covers medicine and diagnostics, protein engineering, biochemistry, genetics, biotechnology research tools and bioinformatics. Areas of specialist expertise include cell and molecular biology, developmental biology, neurobiology and stem cells as well as immunology and vaccine development. Joanna holds a MSc degree in biotech engineering and a Ph.D. in cell and molecular biology from Karolinska Institutet, Stockholm, Sweden. She also has research experience in the field of developmental neurobiology, including stem cell and progenitor cell differentiation and cell-fate specification.

Michael Bzorek (Denmark)

Senior Histotechnologist and project coordinator at the Institute of Surgical Pathology, Zealand University Hospital, Denmark. He has worked within the area of immunohistochemistry for more than 20 years. He has been actively involved in teaching immunohistochemistry since 1997 as an invited lecturer on various international and national courses and meetings. His focus area has been on the technical aspects of immunohistochemistry, particular in the field of protocol optimization. He is a author and co-author of more than 20 publications and since 2010 member of the NordiQC IHC Assessor Group.

Ben Davidson (Norway)

Professor at Faculty of Medicine, University of Oslo and Attending Pathologist, Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. He is main interests are cytopathology and gynecological pathology.  His research is focused on cancer diagnosis, metastasis, cell survival, and studies of prognosis and chemoresistance mainly in cancers involving the serosal cavities like ovarian carcinoma, breast carcinoma and malignant mesothelioma. He is an author of 280 peer-reviewed scientific publications and several book chapters, as well as the editor of a book on serous effusions. He is also a reviewer and a member of editorial boards for leading international peer-reviewed journals, as well as invited speaker on international and national meetings and conferences.

Maria Debiec-Rychter (Belgium)

Is a professor at Department of Human Genetics, KU Leuven, Belgium. Her daily work is focused on diagnostic services (karyotyping and molecular cytogenetic/genetic tests) for the differential diagnosis and predictive selection of solid tumors for standard chemotherapy or targeted therapy with small molecule inhibitors. Her research is concentrated mainly on the development and transfer of the knowledge of molecular biology about sarcomas and brain tumors to the daily medical practice, aiming at improvement of diagnostic, prognostic and predictive tools, identification of new therapeutic targets and promotion of innovative clinical trials in order to evaluate these new targets. She is an author and co-author of 278 publications in peer reviewed journals

Jan Klos (Norway)

Senior Consultant and a Head of the Immunohistochemistry Section in the Department of Pathology, Stavanger University Hospital, Norway.  His professional focus is on diagnostic pathology, particularly hematopathology, pathology of the breast and cytopathology.  He has been actively involved in teaching immunohistochemistry since 2000 as co-organizer of national and international meetings and courses as well as invited lecturer. Since 2009 he is a member of the core group and assessor in NordiQC organization. He is a co-author of more than 40 publications in the field of pathology.

Jerzy Lasota (USA)

Staff Scientist at the Surgical Pathology Section of the Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland. Previously at the Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, D.C., Thomas Jefferson University and Temple University’s Fels Institute for Cancer Research and Molecular Biology in Philadelphia, as a Research Pathologist and in the Molecular Diagnostic Laboratory. He is an author and co-author of 130 publications, including studies on genotyping gastrointestinal stromal tumours and several book chapters on molecular genetics of soft tissue tumors.

Markku Miettinen (USA)

Professor and Head of Surgical Pathology, National Cancer Institute, Bethesda, Maryland, previously at Armed Forces Institute of Pathology, Washington DC and Thomas Jefferson University, Philadelphia, USA. His main interest is pathology of soft tissues. His contribution to definition, biology and diagnosis of Gastrointestinal Stromal Tumors is well recognized. He is a member of editorial boards in several top ranked pathology journals and reviewer in a number of most recognized pathology journals. His list of publications has more than 350 positions including two handbooks on Pathology of Soft Tissues and contributions to WHO Classification of Tumours of Soft Tissue and Bone. In recognition of his work honored with Totten Lecture and Award, University of Pittsburgh in 2005.

Janusz Rys (Poland)

Head of the Department of Tumor Pathology, Centre of Oncology – Maria Sklodowska-Curie Memorial Institute of Oncology, Krakow Branch, a graduate from the Faculty of Medicine, Academy of Medicine in Krakow (1984), pathology board specialist (1991). His interests are focused on diagnostic pathology, especially of the breast and soft tissues, as well as research with application of immunohistochemical and molecular markers in growth and progression of tumors. He is a head and chief executive of several research grants awarded by the Committee of Scientific Research. He is the author and co-author of over 130 publications in medical journals and chapters in four pathology books, as well as the Editor-in-Chief of a quarterly Polish Journal of Pathology. Member of the Polish Society of Pathologists and the European  Society of Pathology.

Hans-Ulrich Schildhaus (Germany)

Professor of Molecular Tumor Pathology and Head of the Molecular Pathology Laboratory  at the Institute of Pathology, authorized representative for Personalized Medicine at the University Medical Center, Georg August University, Göttingen, Germany. He is also a reviewer for  international journals such as the Journal of Pathology, Oncotarget, Virchows Archive, Cancer Research etc. as well as an invited speaker and lecturer of the International Academy of Pathology (IAP) in the areas of molecular pathology, fluorescence in situ hybridization and soft tissue tumors. He is also co-author of more than 100 publications in pathology. His major scientific interest is focused on lung cancer, sarcomas and the deveopment of predictive biomarkers.

Tibor Tot (Sweden)

Associate professor of pathology at the University of Uppsala, head of Laboratory Medicine Dalarna and head of the Department of Pathology and Clinical Cytology at the Central Hospital in Falun, Sweden. He is breast cancer expert of the Swedish Board of Welfare and regular course director of its breast pathology program. The last years he is also one of the faculty members in the breast pathology arm of the European School of Pathology, invited faculty member in European School of Radiology and one of the scientific directors in the European School of Oncology Certificate of Competence in Breast Cancer program. In addition to more than 80 journal articles and 20 book chapters, he published the book Practical Breast Pathology,  an official teaching material of the European School of Pathology. He is also co-author of the Thieme Series on Art and Science of Mammography. With radiological – pathological correlation of breast diseases as the main field of interest, he is repeatedly invited lecturer at the European Congress of Radiology, European Congress of Pathology, and other international and national congresses, symposia, and teaching courses all over the world. He is a member of the Editorial Board of Virchows Archiv, Vojnosanitetski pregled (Belgrade), the Journal of OncoPathology, and the Journal of Solid Tumors, one of the editors of Case Reports in Pathology, member of the European Working Groups for Breast Cancer Screening Pathology and the past chair of the Working Group for Breast Pathology of the European Society of Pathology.

Mogens Vyberg (Denmark)

Professor of Clinical Pathology at Aalborg University, Senior Consultant and the Head of the Laboratory of Immunohistochemistry at the Institute of Pathology, Aalborg University Hospital, Denmark. His main research fields and expertise are immunohistochemistry and gastrointestinal, liver and brain pathology. He is author and co-author of more than 80 scientific papers and several book chapters in these fields as well as the text book Compendium of Applied Immunohistochemistry (Danish; English version scheduled for 2016). He is also a co-founder and scheme director of the Nordic Immunohistochemical Quality Control (NordiQC) with Aalborg Hospital as its domicile which is currently has more than 700 participating pathology laboratories from more than 40 countries.

Organizing/Scientific Committee:

Jan Klos MD Course Director
Members: prof. Janusz Rys and prof. Krzysztof Okon


Wednesday, 18th October 2017
11.00 – 12.00Registration and coffee
12.00 – 12.10Introduction – J. Klos
12.10 – 13.30Technical aspects of IHC and pitfalls – M. Bzorek
13.30 – 14.00Interpretation pitfalls in immunohistochemistry 30′ – J. Klos
14.00 – 14.30Sandwich and coffee break
14.30 – 15.45Approach to unknown primary tumor – J. Klos
15.45 – 16.30Cytokeratins in Diagnostic IHC – M. Vyberg
16.30 – 16.50Coffee break
16.50 – 18.00Presentation of Seminar cases (4) Faculty
19.30 – 22.00Course Dinner
Thursday, 19th October 2017
08.30 – 09.45Gastrointestinal tract (incl. liver and pancreas) – M. Vyberg
09.45 – 10.30GISTs – diagnostic approach (what’s new?) – J. Lasota
10.30 – 10.50Coffee break
10.50 – 11.45Diagnostic IHC of Soft Tissue tumors – M. Miettinen
11.45 – 12.30FISH in soft tissue tumors – J. Rys
12.30 – 13.30Lunch break
13.30 – 15.45Session on Targeted therapy
Molecular & genetic basis of targeted therapy.
Key proteins in cell signaling – M. D-Rychter
IHC surrogates of molecular markers – M. Miettinen
Immunohistochemistry of PDL-1 – H-U. Schildhaus
QA in IHC of targeted therapy – M. Vyberg
15.30 – 15.50Coffee break
15.50 – 17.15Presentation of Seminar cases (6) Faculty
17.15 – 18.00Guest lecture: Identifying inventions and how to protect them
– Practical guide to patenting for pathologists – J. Applequist
Friday, 20th October 2017
08.30 – 09.45IHC in Gynecological pathology – B. Davidson
09.45 – 10.30Germ cell and sex-cord stromal tumors – B. Davidson
10.30 – 10.50Coffee break
10.50 – 11.45Immunohistochemistry of the breast – T. Tot
11.45 – 12.30 Immunocytochemistry – B. Davidson
12.30 – 13.30Lunch break
13.30 – 14.45Practical approach to diagnosis of lymphoma – J. Klos
14.45 – 15.30Immunohistochemistry in pulmonary pathology – H-U. Schildhaus
15.30 – 15.45Concluding remarks and evaluation – J. Klos