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Age 31, parametrium

Case 1  Case 1 slide 1  Case 1 slide 1, Giemsa stained   Case1 slide 2   Case 1 slide 2, Giemsa stained

Cystic PEC-oma   HMB45(+) S100(-) Melan A(-) / DES (-)

Age 63, ovary

Case 2

Poorly differentiated serous carcinoma


Age 52, ovary

Case 3

Adult granulosa cell tumor with hepatoid cells

History: 38 yrs. old, Ovary

Operation (2017):  ovarian tumor – dimensions – 7,5x6x5cm (with an uneven surface dimension – 4cm). Fallopian tube with no pathological changes.

Case 4

Immunohistochemistry:   Positive:  WT1; calretynin; CD56 (in some of the cells); D240 (single cells).

Negative:  OCT4; SALL4; CD117; PLAP; chromogranin; synaptophysin.

Histopathology diagnosis: Sex cord tumor with annular tubules.

50 yrs. consultation case

tumor of the ovary (dimensions 13×13,5×10,5cm) with fallopian tube. In cross-section of  tumor is mainly cystic, focally solid, gray-brown.

Uterus (dimensions 9×7,5×4,2cm), right ovary (dimensions 3,5x2x1,2cm) with fallopian tube, appendix 3,3cm and fragment of omentum with no pathological changes.
Case 5

Immunohistochemistry:   Positive:  inhibin; calretinin; melan-A; CK AE1/AE3 (focally).

Histopathology diagnosis: Sex cord-stromal tumor, not otherwise specified.


45 yrs. old, corpus uteri – leiomyoma (reconsultation)

Ultrasound:  uterine corpus, enlarged – 12,5x11cm, with leiomyomatous changes. Endometrium not detected. Ovaries without any changes .

Operation (10.2017): corpus uteri (dimensions 14,5x15x9,5cm), in cross-section of  corpus uteri visible gray-beige tumor – 12x10cm.

Case 6

Immunohistochemistry:   Positive:  desmin; SMA; caldesmon; ER and PR (80%); CD10 (focally); cyclin D1 (single cells);

Negative:  CD31; CD34; HMB45; ALK1; CD117. Ki67 – 16%.

Histopathology diagnosis: Low grade endometrial stromal sarcoma with smooth muscle differentiation.

Follow up:  12.2017 – removal of the cervix with bilateral ovaries.

History: 49 yrs. old, no previous medical history.

Ultrasound:  corpus uteri and left appendages with normal echogram. Within right appendages oval cystic vascularized lesions size 13x12cm.

Operation (06.2016): the container is tumor separately from uterus (diameter 16cm), with smooth surface.

Uterus (dimensions 9x5x2,5cm), appendix 8,5cm and fragment of omentum with no pathological changes.

Case 7

Immunohistochemistry:   Positive:  AE1/AE3; chromogranin; synaptophysin.

Negative:  CK7; ER; PR; PAX8; inhibin; TTF1.

Ki67 – 50%.

Histopathology diagnosis: Poorly differentiated neuroendocrine carcinoma  G3 (unknown primary site) .

Follow up:  Chemotherapy (09.2016r. – 07.2017r).

Computer tomography (08.2016) – in the area of the Treitz’s ligament, visible infiltration with irregular thickening of the intestinal wall, length approx. 62 mm; near is visible solid change (diam. 27mm) and polycyclic change approx. 29×24 mm.


History: 61 yrs. old, no previous medical history.


Operation (02.2017): uterus (dimensions 12x5x3cm), with bilateral appendages. Within the cervix, isthmus and lower parts of corpus uteri  is seen white, solid infiltration of the  tumor. It involves the entire thickness of the uterine wall, with an ulcer in exocervix.

Case 8 slide 1   Case 8 slide 2   Case 8 slide 3


Immunohistochemistry of squamous cell carcinoma akeratodes:   Positive: CK. Negative:  desmin, SMA.

Immunohistochemistry of leiomyosarcoma cervix: Positive:  SMA; desmin (focally).  Negative:  CK.

Histopathology diagnosis: Squamous cell carcinoma akeratodes G2 of the cervix and leiomyosarcoma  of cervix and corpus uteri.

Follow up:  brachytherapy HDR 2 (01.04, 08.04. 2016r). Chemotherapy (11.04.2017r. – 01.06.2017r).

Computer tomography (09.2017) – disseminated neoplastic process in abdominal cavity and pelvis, with numerous intraperitoneal implants. Metastasis to the right lung.

History: 85 yrs. old, cervical conization – CIN (1997).

Ultrasound: right ovary – tumor with mixt echogenicity, 41x28mm.

Operation (2018):  Right ovary (diameter 7cm). Fallopian tubes, uterus, left ovary with no pathological changes.

Case 9

Immunohistochemistry:   Positive:  WT1; p53; CK AE1/AE3; PAX8 (single cells);                                                                                            Negative:  AFP; beta hCG; CEA; PLAP; CK20; CK7; ER.

Histopathology diagnosis: Malignant Brenner tumor of the ovary.

5 years, vagina

Case 10 (plik do sprawdzenia)

Adenocarcinoma (mucoepidermoid ca vel mesonephric ca

Uterine corpus, 51 years

Case 11

Low-grade endometrial stromal tumor vel UTROSCT (uterine tumor resembling ovarian sex cord tumor)

No rearrangement of JAZF1 gene

VIM(+), CD99(+) ER(+) AR(+)

72 years              vulva

Case 12

Cellular angiofibroma / SFT / angiomatoid fibrous histiocytoma      CD99(+) CD34(+) ER(+) PR(+) Ki67

53 years              Uterine cervix

Case 13

Mesonephric adenoca

29 years              Placenta

Case 14

Intraplacental chorioca   (12456)

35 years              Placenta

Case 15

Placental site trophoblastic tumor (194313)

78 years


DMM (Diffuse Malignant Mesothelioma) vs Malignant mixed mesodermal tumor

49 years

Case 17 slide 1   Case 17 slide 2

Jednocześnie w materiale operacyjnym: rak endometroidny endometrium G1, pT1a mikrorak surowiczy “high grade” jednego z jajowodów serous borderline tumor drugiego jajowodu adenomatoid tumor myometrium adenomioza i endometrioza zewnętrzna